Genetic in failure of conception
Genetic infertility is the inability to conceive or carry a pregnancy to term due to genetic factors. It can affect both males and females, and it can be caused by chromosomal abnormalities, gene mutations, or inherited disorders. Some examples of genetic causes of infertility are:
- In females, conditions such as Turner syndrome, fragile X premutation, and Kallmann syndrome can impair ovarian function and lead to primary ovarian insufficiency (POI) or early menopause.
- In males, microdeletions in the Y chromosome can cause azoospermia (no sperm production) or oligozoospermia (low sperm count). Mutations in genes involved in sperm development, such as NR5A1, can also affect male fertility.
- In both sexes, chromosomal aneuploidies (having an abnormal number of chromosomes) can increase the risk of miscarriage or fetal abnormalities. Single gene defects, such as cystic fibrosis or Tay Sachs disease, can also cause infertility or affect the health of the offspring.
Genetic testing can help diagnose the cause of infertility and guide the treatment options. Depending on the type and severity of the genetic condition, some couples may benefit from assisted reproductive technologies (ART), such as in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Others may opt for preimplantation genetic testing (PGT) to screen the embryos for chromosomal or genetic defects before implantationhttps
